PhytophthoraV1, Main, Exploration, bibRecord, 000874

A Phytophthora capsici RXLR Effector Targets and Inhibits a Plant PPIase to Suppress Endoplasmic Reticulum-Mediated Immunity.

Identifieur interne : 000874 ( Main/Exploration ); précédent : 000873; suivant : 000875

A Phytophthora capsici RXLR Effector Targets and Inhibits a Plant PPIase to Suppress Endoplasmic Reticulum-Mediated Immunity.

Auteurs : Guangjin Fan [République populaire de Chine] ; Yang Yang [République populaire de Chine] ; Tingting Li [République populaire de Chine] ; Wenqin Lu [République populaire de Chine] ; Yu Du [République populaire de Chine] ; Xiaoyu Qiang [République populaire de Chine] ; Qujiang Wen [République populaire de Chine] ; Weixing Shan [République populaire de Chine]

Source :

Molecular plant [ 1752-9867 ] ; 2018.

RBID : pubmed:29864524

Descripteurs français

KwdFr :
- Arabidopsis (génétique), Arabidopsis (microbiologie), Immunité des plantes (génétique), Immunité des plantes (physiologie), Interactions hôte-pathogène (MeSH), Maladies des plantes (génétique), Maladies des plantes (microbiologie), Phytophthora (pathogénicité), Réticulum endoplasmique (métabolisme), Virulence (MeSH), Végétaux génétiquement modifiés (génétique), Végétaux génétiquement modifiés (microbiologie).
MESH :
- génétique : Arabidopsis, Immunité des plantes, Maladies des plantes, Végétaux génétiquement modifiés.
- microbiologie : Arabidopsis, Maladies des plantes, Végétaux génétiquement modifiés.
- métabolisme : Réticulum endoplasmique.
- pathogénicité : Phytophthora.
- physiologie : Immunité des plantes.
- Interactions hôte-pathogène, Virulence.

English descriptors

KwdEn :
- Arabidopsis (genetics), Arabidopsis (microbiology), Endoplasmic Reticulum (metabolism), Host-Pathogen Interactions (MeSH), Phytophthora (pathogenicity), Plant Diseases (genetics), Plant Diseases (microbiology), Plant Immunity (genetics), Plant Immunity (physiology), Plants, Genetically Modified (genetics), Plants, Genetically Modified (microbiology), Virulence (MeSH).
MESH :
- genetics : Arabidopsis, Plant Diseases, Plant Immunity, Plants, Genetically Modified.
- metabolism : Endoplasmic Reticulum.
- microbiology : Arabidopsis, Plant Diseases, Plants, Genetically Modified.
- pathogenicity : Phytophthora.
- physiology : Plant Immunity.
- Host-Pathogen Interactions, Virulence.

Abstract

Phytophthora pathogens secrete a large arsenal of effectors that manipulate host processes to create an environment conducive to pathogen colonization. However, the underlying mechanisms by which Phytophthora effectors manipulate host plant cells still remain largely unclear. In this study, we report that PcAvr3a12, a Phytophthora capsici RXLR effector and a member of the Avr3a effector family, suppresses plant immunity by targeting and inhibiting host plant peptidyl-prolyl cis-trans isomerase (PPIase). Overexpression of PcAvr3a12 in Arabidopsis thaliana enhanced plant susceptibility to P. capsici. FKBP15-2, an endoplasmic reticulum (ER)-localized protein, was identified as a host target of PcAvr3a12 during early P. capsici infection. Analyses of A. thaliana T-DNA insertion mutant (fkbp15-2), RNAi, and overexpression lines consistently showed that FKBP15-2 positively regulates plant immunity in response to Phytophthora infection. FKBP15-2 possesses PPIase activity essential for its contribution to immunity but is directly suppressed by PcAvr3a12. Interestingly, we found that FKBP15-2 is involved in ER stress sensing and is required for ER stress-mediated plant immunity. Taken together, these results suggest that P. capsici deploys an RXLR effector, PcAvr3a12, to facilitate infection by targeting and suppressing a novel ER-localized PPIase, FKBP15-2, which is required for ER stress-mediated plant immunity.

DOI: 10.1016/j.molp.2018.05.009
PubMed: 29864524

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000747
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Le document en format XML

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<term>Plant Diseases (microbiology)</term>
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<term>Réticulum endoplasmique (métabolisme)</term>
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<front><div type="abstract" xml:lang="en">Phytophthora pathogens secrete a large arsenal of effectors that manipulate host processes to create an environment conducive to pathogen colonization. However, the underlying mechanisms by which Phytophthora effectors manipulate host plant cells still remain largely unclear. In this study, we report that PcAvr3a12, a Phytophthora capsici RXLR effector and a member of the Avr3a effector family, suppresses plant immunity by targeting and inhibiting host plant peptidyl-prolyl cis-trans isomerase (PPIase). Overexpression of PcAvr3a12 in Arabidopsis thaliana enhanced plant susceptibility to P. capsici. FKBP15-2, an endoplasmic reticulum (ER)-localized protein, was identified as a host target of PcAvr3a12 during early P. capsici infection. Analyses of A. thaliana T-DNA insertion mutant (fkbp15-2), RNAi, and overexpression lines consistently showed that FKBP15-2 positively regulates plant immunity in response to Phytophthora infection. FKBP15-2 possesses PPIase activity essential for its contribution to immunity but is directly suppressed by PcAvr3a12. Interestingly, we found that FKBP15-2 is involved in ER stress sensing and is required for ER stress-mediated plant immunity. Taken together, these results suggest that P. capsici deploys an RXLR effector, PcAvr3a12, to facilitate infection by targeting and suppressing a novel ER-localized PPIase, FKBP15-2, which is required for ER stress-mediated plant immunity.</div>
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<Title>Molecular plant</Title>
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<ArticleTitle>A Phytophthora capsici RXLR Effector Targets and Inhibits a Plant PPIase to Suppress Endoplasmic Reticulum-Mediated Immunity.</ArticleTitle>
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<Abstract><AbstractText>Phytophthora pathogens secrete a large arsenal of effectors that manipulate host processes to create an environment conducive to pathogen colonization. However, the underlying mechanisms by which Phytophthora effectors manipulate host plant cells still remain largely unclear. In this study, we report that PcAvr3a12, a Phytophthora capsici RXLR effector and a member of the Avr3a effector family, suppresses plant immunity by targeting and inhibiting host plant peptidyl-prolyl cis-trans isomerase (PPIase). Overexpression of PcAvr3a12 in Arabidopsis thaliana enhanced plant susceptibility to P. capsici. FKBP15-2, an endoplasmic reticulum (ER)-localized protein, was identified as a host target of PcAvr3a12 during early P. capsici infection. Analyses of A. thaliana T-DNA insertion mutant (fkbp15-2), RNAi, and overexpression lines consistently showed that FKBP15-2 positively regulates plant immunity in response to Phytophthora infection. FKBP15-2 possesses PPIase activity essential for its contribution to immunity but is directly suppressed by PcAvr3a12. Interestingly, we found that FKBP15-2 is involved in ER stress sensing and is required for ER stress-mediated plant immunity. Taken together, these results suggest that P. capsici deploys an RXLR effector, PcAvr3a12, to facilitate infection by targeting and suppressing a novel ER-localized PPIase, FKBP15-2, which is required for ER stress-mediated plant immunity.</AbstractText>
<CopyrightInformation>Copyright © 2018 The Author. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
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<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>06</Month>
<Day>01</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Mol Plant</MedlineTA>
<NlmUniqueID>101465514</NlmUniqueID>
<ISSNLinking>1674-2052</ISSNLinking>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D017360" MajorTopicYN="N">Arabidopsis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004721" MajorTopicYN="N">Endoplasmic Reticulum</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057865" MajorTopicYN="N">Plant Immunity</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Avr3a</Keyword>
<Keyword MajorTopicYN="Y">ER stress</Keyword>
<Keyword MajorTopicYN="Y">FKBP</Keyword>
<Keyword MajorTopicYN="Y">Phytophthora capsici</Keyword>
<Keyword MajorTopicYN="Y">RXLR effector</Keyword>
<Keyword MajorTopicYN="Y">immunity</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>11</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>05</Month>
<Day>25</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>05</Month>
<Day>27</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>6</Month>
<Day>5</Day>
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<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>3</Month>
<Day>19</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29864524</ArticleId>
<ArticleId IdType="pii">S1674-2052(18)30186-2</ArticleId>
<ArticleId IdType="doi">10.1016/j.molp.2018.05.009</ArticleId>
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<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Fan, Guangjin" sort="Fan, Guangjin" uniqKey="Fan G" first="Guangjin" last="Fan">Guangjin Fan</name>
</noRegion>
<name sortKey="Du, Yu" sort="Du, Yu" uniqKey="Du Y" first="Yu" last="Du">Yu Du</name>
<name sortKey="Li, Tingting" sort="Li, Tingting" uniqKey="Li T" first="Tingting" last="Li">Tingting Li</name>
<name sortKey="Lu, Wenqin" sort="Lu, Wenqin" uniqKey="Lu W" first="Wenqin" last="Lu">Wenqin Lu</name>
<name sortKey="Qiang, Xiaoyu" sort="Qiang, Xiaoyu" uniqKey="Qiang X" first="Xiaoyu" last="Qiang">Xiaoyu Qiang</name>
<name sortKey="Shan, Weixing" sort="Shan, Weixing" uniqKey="Shan W" first="Weixing" last="Shan">Weixing Shan</name>
<name sortKey="Wen, Qujiang" sort="Wen, Qujiang" uniqKey="Wen Q" first="Qujiang" last="Wen">Qujiang Wen</name>
<name sortKey="Yang, Yang" sort="Yang, Yang" uniqKey="Yang Y" first="Yang" last="Yang">Yang Yang</name>
</country>
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A Phytophthora capsici RXLR Effector Targets and Inhibits a Plant PPIase to Suppress Endoplasmic Reticulum-Mediated Immunity.

A Phytophthora capsici RXLR Effector Targets and Inhibits a Plant PPIase to Suppress Endoplasmic Reticulum-Mediated Immunity.

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